Effect of slightly elevated progesterone on hCG trigger day on clinical pregnancy rate in GnRH-ant IVF/ICSI cycles
Effect of slightly elevated progesterone on hCG trigger day on clinical pregnancy rate in GnRH-ant IVF/ICSI cycles
Blog Article
Abstract Background It was been agreed that significantly elevated progesterone level on the hCG trigger day have detrimental effect on clinical outcomes in IVF/ICSI cycles.However, few studies explored whether slightly elevated progesterone level also same impact on clinical outcomes.Methods We retrospectively studies the effect of slightly elevated progesterone level on outcomes of IVF/ICSI in GnRH-ant cycles.Propensity score matching was used to confounding variables.The women were divided into two groups according to the progesterone level: Group 1: < 1.
0 ng/ml; Digital Scale Group 2: 1.0 ng/ml–1.5 ng/ml.Then compare the clinical pregnancy rate (CPR) between the two groups.Result A total of 847 IVF/ICSI cycles were included in the present study.
The average CPR per transfer cycle was 51.7%.CPR of group 1 was 55.22%, significantly higher than that of group 2 (40.66%, P = 0.
013).Progesterone level on the day of hCG injection was further evaluated at threshold increments of 0.1 ng/ml, and the CPR was decreased dramatically once Dryer Door Switch the progesterone level higher than 1.4 ng/ml.Conclusion The slight elevation progesterone level on the hCG trigger day may have a negative effect on the clinical pregnancy in GnRH-ant cycles.
In the case of progesterone > 1.4 ng/ml on the hCG injection day, freeze-all strategy was recommended.Summary The present retrospective study aimed to evaluate the effect of slightly elevated progesterone (1.0 ng/ml ~ 1.5 ng/ml) on outcomes of IVF/ICSI in GnRH-ant cycles.
Slightly elevated progesterone level leaded to significant lower clinical pregnancy rate (CPR) that that of group with normal progesterone level (40.66% vs.55.22%, P = 0.013).
The CPR was decreased dramatically once the progesterone level higher than 1.4 ng/ml.So slightly elevated progesterone level on the trigger day may have a negative effect on the clinical pregnancy in GnRH-ant cycles.In the case of progesterone > 1.4 ng/ml on the hCG injection day, freeze-all strategy was recommended.